期刊
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
卷 10, 期 8, 页码 1729-1737出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.nano.2014.05.015
关键词
Dental implant; Nano; Osseointegration; Ultrastructure; Electron microscopy; Bone bonding
资金
- Swedish Research Council [K2012-52X-09495-25-3]
- BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy
- Region Vastra Gotaland
- ALF/LUA grant
- IngaBritt and Arne Lundberg Foundation
- Dr. Felix Neubergh Foundation
- Hjalmar Svensson Foundation
- Swedish Government Strategic Funding of Materials Science Area of Advance
Evaluation of the fine structure of the bone-implant interface in humans is a prerequisite for a deepened understanding of structure-function relationships with nano-modified biomaterials. In this study, three clinically stable, yet retrieved, laser-modified dental implants were evaluated using histological and interface ultrastructural analyses. The cumulative results for all threads containing intact tissue showed remodeled Haversian bone with bone area and bone-implant contact in excess of 85% and 80%, respectively. Collagen fibrils, laid down parallel to the surface oxide layer, were mineralized by plate-like crystallites of stoichiometrically relevant (Ca/P ratios 1.30-1.67) bone-apatite. An overlap of titanium, oxygen, calcium and phosphorus signals indicated the gradual intermixing of bone-apatite and the nano-rough surface oxide. These results suggest that bone bonding to nano-textured titanium implant surfaces is promoted in human jaw-bone after functional loading. From the Clinical Editor: In this study, newly developed and laser-modified titanium dental implants demonstrate strong evidence for implant-osseo integration basen on the surface and chemical analysis of three clinically stable dental implants. (C) 2014 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据