期刊
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
卷 9, 期 8, 页码 1192-1202出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.nano.2013.05.012
关键词
Gold nanorods; Magnetophoresis; Plasmonic photothermal therapy; Photoacoustic tomography
资金
- John R. Oishei Foundation
- University at Buffalo Clinical and Translational Research Center
- Buffalo Translational Consortium
- Roswell Park Alliance Foundation
- IT Consilience Creative Program of MKE
- NIPA [C1515-1121-0003]
- NRF grant of Korea government (MSIP) [2011-0030075]
- University at Buffalo
We present a magnetoplasmonic nanoplatform combining gold nanorods (GNR) and iron-oxide nanoparticles within phospholipid-based polymeric nanomicelles (PGRFe). The gold nanorods exhibit plasmon resonance absorbance at near infrared wavelengths to enable photoacoustic imaging and photothermal therapy, while the Fe3O4 nanoparticles enable magnetophoretic control of the nanoformulation. The fabricated nanoformulation can be directed and concentrated by an external magnetic field, which provides enhancement of a photoacoustic signal. Application of an external field also leads to enhanced uptake of the magnetoplasmonic formulation by cancer cells in vitro. Under laser irradiation at the wavelength of the GNR absorption peak, the PGRFe formulation efficiently generates plasmonic nanobubbles within cancer cells, as visualized by confocal microscopy, causing cell destruction. The combined magnetic and plasmonic functionalities of the nanoplatform enable magnetic field-directed, imaging-guided, enhanced photo-induced cancer therapy. From the Clinical Editor: In this study, a nano-formulation of gold nanorods and iron oxide nanoparticles is presented using a phospholipid micelle-based delivery system for magnetic field-directed and imaging-guided photo-induced cancer therapy. The gold nanorods enable photoacoustic imaging and photothermal therapy, while the Fe3O4 nanoparticles enable magnetophoretic control of the formulation. This and similar systems could enable more precise and efficient cancer therapy, hopefully in the near future, after additional testing. (C) 2013 Elsevier Inc. All rights reserved.
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