期刊
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
卷 9, 期 3, 页码 439-448出版社
ELSEVIER
DOI: 10.1016/j.nano.2012.08.001
关键词
Cerium oxide nanoparticles; Antioxidant; Endometriosis; Anti-angiogenesis
资金
- Indian Council of Medical Research
- Department of Science and Technology, Government of India
- National Science Foundation [NIRT: 0708172]
Cerium oxide nanoparticles (nanoceria) have recently received attention from the scientific community due to their unique free radicals (specially superoxide radical and hydrogen peroxide) scavenging property in biological system, both in vitro and in vivo. It is suggested that free radicals play an important role in the pathogenesis of endometriosis. In this study we have shown that nanoceria mitigate the endometrial lesions induced in mice model by decreasing oxidative stress and inhibiting angiogenesis. Moreover, nanoceria were also observed to protect endometriosis-related adverse effects on the oocytes, which is critical for successful pregnancy. Summarizing, nanoceria have shown promising efficacy against endometriosis related pathogenesis. From the Clinical Editor: Free radicals have been implemented in the pathogenesis of endometriosis. In a murine model the authors demonstrated successful treatment of endometriosis with nanoceria, and protection of endometriosis-related adverse effects on the oocytes, paving the way to potential clinical translational applications in the future. (C) 2013 Elsevier Inc. All rights reserved.
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