期刊
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
卷 9, 期 7, 页码 1027-1035出版社
ELSEVIER
DOI: 10.1016/j.nano.2013.03.007
关键词
Cholesterol; Sitosterol; Nanosystem
资金
- German Research Foundation (DFG) [KE 920/2-2]
Due to hypocholesterolemic effects, sitosterol is used in functional foods and nanoscale dispersions. To investigate the influence of dietary sitosterol on sterol concentrations in Dunkin Hartley guinea pigs, seven groups consisting of eight animals each were fed either a basal diet (BD), a high-cholesterol diet (HC) or a high-cholesterol diet supplemented with crystalline commonscale (CCS), microscale (CMS, low-dosed: CMLS), nanoscale (CNS) or emulsified nanoscale (ENS) sitosterol. When compared to HC group, all sitosterol formulations decreased liver cholesterol concentrations. No differences in cholesterol or sitosterol concentration were found in plasma and liver between CCS, CMS, CNS, and ENS groups. Apparent cholesterol digestibility decreased by increasing crystalline microscale sitosterol doses. Despite a lower sitosterol intake, ENS group had higher serosal sitosterol concentrations in jejunum than CNS group. To elucidate an impact of the sitosterol nanosystem on gut tissues further studies are necessary. (C) 2013 Elsevier Inc. All rights reserved.
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