期刊
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
卷 8, 期 7, 页码 1133-1142出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.nano.2012.02.003
关键词
Nanoparticles; Blood brain barrier; Focused ultrasound; Central nervous system; Magnetic resonance imaging
资金
- Canadian Institutes of Health Research (CIHR) [MOP-74610]
- Congress of Neurological Surgeons Penfield Award
- Brain Tumour Foundation of Canada
- Brainchild - Canada
- Canadian Research Chairs program
- National Institute of Health (NIH) [EB003268]
The blood brain barrier (BBB) is a major impediment to the delivery of therapeutics into the central nervous system (CNS). Gold nanoparticles (AuNPs) have been successfully employed in multiple potential therapeutic and diagnostic applications outside the CNS. However, AuNPs have very limited biodistribution within the CNS following intravenous administration. Magnetic resonance imaging guided focused ultrasound (MRgFUS) is a novel technique that can transiently increase BBB permeability allowing delivery of therapeutics into the CNS. MRgFUS has not been previously employed for delivery of AuNPs into the CNS. This work represents the first demonstration of focal enhanced delivery of AuNPs into the CNS using MRgFUS in a rat model both safely and effectively. Histologic visualization and analytical quantification of AuNPs within the brain parenchyma suggest BBB transgression. These results suggest a role for MRgFUS in the delivery of AuNPs with therapeutic potential into the CNS for targeting neurological diseases. From the Clinical Editor: Gold nanoparticles have been successfully utilized in experimental diagnostic and therapeutic applications; however, the blood-brain barrier (BBB) is not permeable to these particles. In this paper, the authors demonstrated that MRI guided focused ultrasound is capable to transiently open the BBB thereby enabling CNS access. (C) 2012 Elsevier Inc. All rights reserved.
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