期刊
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
卷 8, 期 3, 页码 275-290出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.nano.2011.08.017
关键词
Iron oxide; Magnetic resonance imaging (MRI); Contrast agent; Targeting; Cancer cell lines
资金
- Natural Sciences and Engineering Research Council of Canada (NSERC)
Superparamagnetic iron oxide nanoparticles (SPIONs) have proven to be highly effective contrast agents for the magnetic resonance imaging diagnosis of solid tumors. This review examines the various techniques that are available to selectively target SPIONs toward a wide variety of cancerous tissues, with specific attention given to how the surface properties imparted by various targeting ligands affect the particles tissue distribution and pharmacokinetics. An in-depth examination of the various human cell lines utilized to test the assorted targeting methods is also presented, as well as an overview of the various types of cancer against which each targeting method has been utilized for both in vivo and in vitro studies.
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