期刊
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
卷 8, 期 4, 页码 419-423出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.nano.2012.02.011
关键词
Carbon nanofiber; Neural interface; Neural chip; Nano-neuron interface; Electrophysiology
资金
- National Institute for Biomedical Imaging and Bioengineering [1-R01EB006316]
- Material Sciences and Engineering Division of the DOE Office of Science [DE-AC05-00OR22725]
- UT-Battelle, LLC
- Laboratory Directed Research and Development of the Oak Ridge National Laboratory
- Material Sciences and Engineering Division of the DOE Office of Science
- National Natural Science Foundation of China [61102042]
- Youth Innovation Promotion Association, Chinese Academy of Sciences
- [1R21NS052794]
Neural chips, which are capable of simultaneous multisite neural recording and stimulation, have been used to detect and modulate neural activity for almost thirty years. As neural interfaces, neural chips provide dynamic functional information for neural decoding and neural control. By improving sensitivity and spatial resolution, nano-scale electrodes may revolutionize neural detection and modulation at cellular and molecular levels as nano-neuron interfaces. We developed a carbon-nanofiber neural chip with lithographically defined arrays of vertically aligned carbon nanofiber electrodes and demonstrated its capability of both stimulating and monitoring electrophysiological signals from brain tissues in vitro and monitoring dynamic information of neuroplasticity. This novel nano-neuron interface may potentially serve as a precise, informative, biocompatible, and dual-mode neural interface for monitoring of both neuroelectrical and neurochemical activity at the single-cell level and even inside the cell. From the Clinical Editor: The authors demonstrate the utility of a neural chip with lithographically defined arrays of vertically aligned carbon nanofiber electrodes. The new device can be used to stimulate and/or monitor signals from brain tissue in vitro and for monitoring dynamic information of neuroplasticity both intracellularly and at the single cell level including neuroelectrical and neurochemical activities. (C) 2012 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据