期刊
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
卷 7, 期 2, 页码 220-227出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.nano.2010.10.006
关键词
Osseointegration; Titanium; Laser; Biomechanics; Nanotechnology; Bone
资金
- Institute of Biomaterials and Cell Therapy (IBCT)
- Swedish Research Council [K2006-73X-09495-16-3]
- BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy
- Region Vastra Gotaland LUA/ALF Optimization of osseointegration
This study explored whether laser-induced, site-specific implant surface modifications with micro-and nano-scale topography were able to promote bone formation. The aim was to evaluate the biomechanical and histological response to partly laser-modified titanium implants in comparison with machined implants. After an early 8-week healing period in rabbit tibia and femur, a 250% increase in removal torque was demonstrated for the partly laser-modified surface. Further, different fracture mechanisms were demonstrated for the two surfaces. Histologically, significantly more bone was found in direct contact with the laser-modified surface for the implants in the tibia sites, and a similar amount of bone tissue was observed in contact with the implant in the femoral sites. In conclusion, an improved bone-implant interface anchorage was promoted by an increase in micro-and nano-scale implant surface topography and surface oxide induced by topological laser treatment. From the Clinical Editor: Nanosized grooves in titanium implants markedly improve bone-implant anchorage by increasing the amount of bone formed in direct contact with the metal prosthesis. (C) 2011 Elsevier Inc. All rights reserved.
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