期刊
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
卷 6, 期 5, 页码 619-633出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.nano.2010.01.009
关键词
Focal adhesions; Biomaterials; Nanotopography; Cell signaling
资金
- AO Research Fund, Switzerland [04-D81]
- U.S. National Institutes of Health, Nanomedicine Roadmap Initiative [PN2EY016586]
- Biology and Biological Sciences Research Council
- NATIONAL EYE INSTITUTE [PN2EY016586] Funding Source: NIH RePORTER
As materials technology and the field of biomedical engineering advances, the role of cellular mechanisms, in particular adhesive interactions with implantable devices, becomes more relevant in both research and clinical practice. A key tenet of medical device design has evolved from the exquisite ability of biological systems to respond to topographical features or chemical stimuli, a process that has led to the development of next-generation biomaterials for a wide variety of clinical disorders. In vitro studies have identified nanoscale features as potent modulators of cellular behavior through the onset of focal adhesion formation. The focus of this review is on the recent developments concerning the role of nanoscale structures on integrin-mediated adhesion and cellular function with an emphasis on the generation of medical constructs with regenerative applications.
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