期刊
NANOMEDICINE
卷 9, 期 10, 页码 1581-1588出版社
FUTURE MEDICINE LTD
DOI: 10.2217/NNM.14.92
关键词
biomimetics; biosynthetic polymers; carbon nanotubues; cell proliferation; cytoskeleton; microtubule stability; tubulin polymerization
资金
- Spanish MINECO Project [PI13/01074]
- Fundacion Eugenio Rodriguez Pascual (Ayudas a la Investigation Biomedica)
Carbon nanotubes (CNTs) and microtubules are both hollow nanofibers and have similar dimensions; they both self-assemble and form bundles. These common features prompt their association into biosynthetic polymers in vitro and in vivo. Unlike CNTs, microtubules are highly dynamic protein polymers essential for cell proliferation and migration. Interaction between these filaments inside live cells leads to microtubule dysfunction, mitotic arrest and cell death. Thus, CNTs behave as spindle poisons, same as taxanes, vinca alkaloids or epotilones. Recent findings support the idea that CNTs represent a ground-breaking type of synthetic microtubule-stabilizing agents that could play a pivotal role in future cancer treatments in combination to traditional antineoplastic drugs. Here we review the potential use of CNTs in cancer medicine.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据