期刊
NANOMEDICINE
卷 9, 期 13, 页码 2041-2057出版社
FUTURE MEDICINE LTD
DOI: 10.2217/NNM.14.136
关键词
cancer imaging; drug delivery; gold nanoshells; hyperthermia; photoacoustic; siRNA; surface plasmon resonance; thermal ablation; tumor penetration; tumor targeting
资金
- NIH NCI SPORE in Brain Cancer Career Development Award [2 P50 CA127001-06]
- John S Dunn Foundation
Gold nanoshells (AuNSs) present a vivid example of integrating nanoscience in order to solve a biomedical problem. AuNSs exhibit tunable surface plasmon resonance, which can be tuned to the near-infrared region in order to realize optimal tissue penetration. The highly efficient light-to-heat transformation by AuNSs during laser irradiation causes thermal damage to the tumor without damaging healthy organs. Transient nanobubbles can form around AuNSs during laser treatment and induce mechanical stress specifically in tumor cells. AuNSs also serve as a versatile platform for the delivery of various diagnostic and therapeutic agents. In this article, we describe the physicochemical properties of AuNSs in the context of their design, preparation and application in cancer theranostics. Ultimately, we look beyond the current research on AuNSs and discussed future challenges to their successful translation into clinical use.
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