期刊
NANOMEDICINE
卷 9, 期 11, 页码 1715-1726出版社
FUTURE MEDICINE LTD
DOI: 10.2217/NNM.14.106
关键词
antitumor therapy; heat-shock proteins; hyperthermia; immune response; magnetic nanoparticles; tumor immunity
资金
- Ministry of Education, Culture, Sports, Science, and Technology of Japan [24591897]
- Grants-in-Aid for Scientific Research [24591897] Funding Source: KAKEN
Magnetic nanoparticle-mediated hyperthermia (MNHT) generates heat to a local tumor tissue of above 43 degrees C without damaging surrounding normal tissues. By applying MNHT, a significant amount of heat-shock proteins is expressed within and around the tumor tissues, inducing tumor-specific immune responses. In vivo experiments have indicated that MNHT can induce the regression of not only a local tumor tissue exposed to heat, but also distant metastatic tumors unexposed to heat. In this article, we introduce recent progress in the application of MNHT for antitumor treatments and summarize the mechanisms and processes of its biological effects during antitumor induction by MNHT. Several clinical trials have been conducted indicating that the MNHT system may add a promising and novel approach to antitumor therapy.
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