期刊
NANOMEDICINE
卷 9, 期 2, 页码 267-278出版社
FUTURE MEDICINE LTD
DOI: 10.2217/nnm.13.70
关键词
cancer therapy; drug delivery systems; drug targeting; medical imaging; nanomedicine; nanostructures
资金
- NIH [1R01CA149359, 1R01EB003975]
- 'Med into Grad' initiative of the Howard Hughes Medical Institute
- National Cancer Institute of the NIH [5F31CA150566]
Aim: A large fraction of the administered dose of nanoparticles (NPs) localizes into nontarget tissue, which could be due to the heterogeneous population of NPs. Materials & methods: To investigate the impact of the above issue, we simultaneously tracked the biodistribution using optical imaging of two different sized poly(d,l-lactide co-glycolide) NPs, which also varied in their surface charge and texture, in a prostate tumor xenograft mouse model. Results: Although formulated using the same polymer and emulsifier concentration, small NPs were neutral (S-neutral-NPs), whereas large NPs were anionic (L-anionic-NPs). Simultaneous injection of these NPs, representing heterogeneity, shows significantly different biodistribution. S-neutral-NPs demonstrated longer circulation time than L-anionic-NPs (t(1/2) = 96 vs 13 min); accounted for 75% of total NPs accumulated in the tumor; and showed 13-fold greater tumor to liver signal intensity ratio than L-anionic-NPs. Conclusion: The data underscore the importance of formulating nanocarriers of specific properties to enhance their targeting efficacy. Original submitted 7 September 2012; Revised submitted 12 December 2012; Published online 26 June 2013
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据