期刊
NANOMEDICINE
卷 9, 期 9, 页码 1353-1362出版社
FUTURE MEDICINE LTD
DOI: 10.2217/NNM.13.138
关键词
body fat; body weight; cholesterol; high-fat diet; mesoporous silica; obesity
资金
- Swedish Research Council [2009-4716]
- VR-M from the Swedish Research Council
- Novonordiskfonden
- Stiftelsen Svenska Diabetesforbundets Forskningsfond
- Magnus Bergvall foundation
- Carl Tryggers foundation
Background: There is a need for medical treatments to curb the rising rate of obesity. Weight reduction is correlated with a decrease in associated risk factors and cholesterol levels in humans. Amorphous silica particles have been found to exert a hypocholesterolemic effect in humans, making them popular dietary additives. Aim: To investigate the effect of mesoporous silica, which possess sharp pore size distributions, on: weight loss, cholesterol, triglycerides and glucose blood levels in obese mice. Materials & methods: Mesoporous silicas with differing pore size were mixed in the high-fat diet of obese mice. Results: Animals receiving large pore mesoporous silica with a high-fat diet show a significant reduction in body weight and fat composition, with no observable negative effects. Conclusion: Pore size is an important parameter for reduction of body weight and body fat composition by mesoporous silica, demonstrating promising signs for the treatment of obesity.
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