期刊
NANOMEDICINE
卷 8, 期 9, 页码 1509-1528出版社
FUTURE MEDICINE LTD
DOI: 10.2217/NNM.13.118
关键词
active targeting; drug delivery; liposome; passive targeting; receptor; tumor vasculature
资金
- NIH [RO1 CA121838, RO1 CA128486]
The use of liposomes for drug delivery began early in the history of pharmaceutical nanocarriers. These nanosized, lipid bilayered vesicles have become popular as drug delivery systems owing to their efficiency, biocompatibility, nonimmunogenicity, enhanced solubility of chemotherapeutic agents and their ability to encapsulate a wide array of drugs. Passive and ligand-mediated active targeting promote tumor specificity with diminished adverse off-target effects. The current field of liposomes focuses on both clinical and diagnostic applications. Recent efforts have concentrated on the development of multifunctional liposomes that target cells and cellular organelles with a single delivery system. This review discusses the recent advances in liposome research in tumor targeting.
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