期刊
NANOMEDICINE
卷 8, 期 4, 页码 603-621出版社
FUTURE MEDICINE LTD
DOI: 10.2217/NNM.13.50
关键词
bottom-up approach; in situ biofabrication; nanoscale structure; skin regeneration; tissue engineering; top-down approach; wound healing
资金
- European Regional Development Fund through the Programa Operacional Factores de Competitividade - COMPETE
- Portuguese funds through Fundacao para a Ciencia e a Tecnologia
- [PEST-OE/EME/UI4044/2011]
- [PEST-C/SAU/LA0002/2011]
- Fundação para a Ciência e a Tecnologia [PEst-C/SAU/LA0002/2011] Funding Source: FCT
Skin is the largest organ of human body, acting as a barrier with protective, immunologic and sensorial functions. Its permanent exposure to the external environment can result in different kinds of damage with loss of variable volumes of extracellular matrix. For the treatment of skin lesions, several strategies are currently available, such as the application of autografts, allografts, wound dressings and tissue-engineered substitutes. Although proven clinically effective, these strategies are still characterized by key limitations such as patient morbidity, inadequate vascularization, low adherence to the wound bed, the inability to reproduce skin appendages and high manufacturing costs. Advanced strategies based on both bottom-up and top-down approaches offer an effective, permanent and viable alternative to solve the abovementioned drawbacks by combining biomaterials, cells, growth factors and advanced biomanufacturing techniques. This review details recent advances in skin regeneration and repair strategies, and describes their major advantages and limitations. Future prospects for skin regeneration are also outlined.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据