期刊
NANOMEDICINE
卷 8, 期 10, 页码 1611-1624出版社
FUTURE MEDICINE LTD
DOI: 10.2217/NNM.12.168
关键词
atherosclerotic plaque; diethylene triamine pentaacetic acid; dual-modality probe; gold nanorod; intravascular photoacoustic imaging; macrophage; methoxy-PEG-thiol; MRI; N-hydroxy succinimide; photoacoustic imaging
资金
- National Basic Research Program of China [2011CB910402, 2010CB732602]
- Program for Changjiang Scholars and Innovative Research Team in University [IRT0829]
- National Natural Science Foundation of China [81127004, 11104087]
- Scientific Research Foundation of Graduate School of South China Normal University [2012kyjj122, 2012kyjj117]
Aim: One of the features of high-risk atherosclerotic plaques is the preponderance of macrophages. Gadolinium(III)-gold nanorods (Gd-III-GNRs) have been developed as a dual-modality probe for MRI and photoacoustic imaging (PAI) to trace macrophages for determining the degree of inflammation. Materials & methods: Gd-III-GNRs were utilized for MRI and PAI dual-modality detection of macrophages in living mice and ex vivo simulated macrophage-rich plaque. Results: Gd-III-GNRs were shown to be endocytosed by macrophages in vitro. Macrophages labeled with Gd-III-GNRs were detected by both PAI and MRI. With Gd-III-GNRs, it is possible to institute a multiscale complementary imaging protocol: MRI can screen to identify the location of the probe-phagocytosed macrophages, and intravascular PAI provides a subsequent precise morphology to quantify the infiltration area and invasion depth of macrophages in the arterial wall. Conclusion: This new dual-modality nanoparticle approach has promise for enabling quantitative detection of macrophages in atherosclerotic plaques.
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