期刊
NANOMEDICINE
卷 7, 期 9, 页码 1425-1442出版社
FUTURE MEDICINE LTD
DOI: 10.2217/NNM.12.109
关键词
cell therapy; drug delivery; forced transport; magnetic cell seeding; magnetic cell stimulation; magnetic targeting; patterned cell assemblies; superparamagnetic nanoparticles; time-varied magnetic field; tissue engineering
资金
- Louis and Bessie Stein Family foundation through the Drexel University College of Medicine
- National Heart, Lung and Blood Institute [5R01HL107771-02]
- European Union
- Azrieli Foundation
- American Associates of the Ben-Gurion University of the Negev, Israel
Magnetic-based systems utilizing superparamagnetic nanoparticles and a magnetic field gradient to exert a force on these particles have been used in a wide range of biomedical applications. This review is focused on drug targeting applications that require penetration of a cellular barrier as well as strategies to improve the efficacy of targeting in these biomedical applications. Another focus of this review is regenerative applications utilizing tissue engineered scaffolds prepared with the aid of magnetic particles, the use of remote actuation for release of bioactive molecules and magneto mechanical cell stimulation, cell seeding and cell patterning.
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