期刊
NANOMEDICINE
卷 7, 期 7, 页码 1029-1043出版社
FUTURE MEDICINE LTD
DOI: 10.2217/NNM.12.2
关键词
brain edema; contrast-enhanced ultrasound; focused ultrasound; intracerebral hemorrhage; microbubbles; nitroxide-radical; containing nanoparticle; oxidative stress; reactive oxygen species; redox-polymer drug; self-assembling polymer micelle
资金
- World Premier International Research Center Initiative (WPI Initiative) on Materials Nanoarchitronics of the Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan
- [21240050]
- [22800004]
- Grants-in-Aid for Scientific Research [24659014, 21240050, 20106011, 24659920, 22800004] Funding Source: KAKEN
Background: Intracerebral hemorrhage is reported to induce the generation of reactive oxygen species and oxidative DNA damage in the brain. Aims: We aimed to examine whether our designed redox polymer nanoparticle could reduce intracerebral hemorrhage induced by 1-MHz focused ultrasound sonication coupled with microbubble treatment. Materials & methods: Contrast-enhanced ultrasound imaging, frozen section, brain edema, neurologic deficit, the number of morphologically normal neurons, DNA oxidization and superoxide anion generation were used to investigate the neuroprotective effect of redox polymer nanoparticles. Results: We confirmed that the 1-MHz focused ultrasound coupled with microbubble produced intracerebral hemorrhage and showed that the redox polymer nanoparticle ameliorates intracerebral hemorrhage-induced brain edema, neurological deficit and oxidative damage. Conclusion: These results suggest that redox polymer nanoparticle is a potential therapeutic agent for intracerebral hemorrhage induced by focused ultrasound.
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