期刊
NANOMEDICINE
卷 6, 期 4, 页码 715-728出版社
FUTURE MEDICINE LTD
DOI: 10.2217/NNM.11.19
关键词
circulation time; nanoparticle; PEG; PEG conjugation; PEG length; PEG quantitation; polyethylene glycol
资金
- NCI ICMIC [P50CA114747, NCI CCNE-TU54 U54CA151459, NIBIB BRP 5-RO1-EBB000312, NCI U01 EDRN CA152737]
- Doris Duke Foundation
- Canary Foundation
- Ben and Catherine Ivy Foundation
- Sir Peter Michael Foundation
- SMIS [R25 CA118681]
Nanoparticles are an essential component in the emerging field of nanomedical imaging and therapy. When deployed in vivo, these materials are typically protected from the immune system by polyethylene glycol (PEG). A wide variety of strategies to coat and characterize nanoparticles with PEG has established important trends on PEG size, shape, density, loading level, molecular weight, charge and purification. Strategies to incorporate targeting ligands are also prevalent. This article presents a background to investigators new to stealth nanoparticles, and suggests some key considerations needed prior to designing a nanoparticle PEGylation protocol and characterizing the performance features of the product.
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