期刊
NANOMEDICINE
卷 6, 期 6, 页码 995-1009出版社
FUTURE MEDICINE LTD
DOI: 10.2217/NNM.11.31
关键词
functionalized-nanoparticle; in vitro; molecular affinity; neuropilin-1; peptide; photodynamic efficiency
资金
- Ligue Nationale Contre le Cancer
- ANR [ANR-08-PCVI-0021-01]
- Agence Nationale de la Recherche (ANR) [ANR-08-PCVI-0021] Funding Source: Agence Nationale de la Recherche (ANR)
Aim: The strategy developed aims to favor the vascular effect of photodynamic therapy by targeting tumor-associated vascularization using peptide-functionalized nanoparticles. We previously described the conjugation of a photosensitizer to a peptide targeting neuropilin-1 overexpressed in tumor angiogenic vessels. Materials & Methods: In this study, we have designed and photophysically characterized a multifunctional nanoparticle consisting of a surface-localized tumor vasculature targeting peptides and encapsulated photodynamic therapy and imaging agents. Results & Conclusion: The elaboration of these multifunctional silica-based nanoparticles is reported. Nanoparticles functionalized with approximately 4.2 peptides bound to recombinant neuropilin-1 protein. Nanoparticles conferred photosensitivity to cells overexpressing neuropilin-1, providing evidence that the chlorin grafted within the nanoparticle matrix can be photoactivated to yield photocytotoxic effects in vitro.
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