期刊
NANOMEDICINE
卷 6, 期 2, 页码 351-364出版社
FUTURE MEDICINE LTD
DOI: 10.2217/NNM.10.136
关键词
CAM model; cancer; cell cycle; CPMV; EPR effects; PEGylation; vimentin; viral nanoparticles
资金
- American Heart Association
- NIH [K99 EB009105, R01 CA112075]
- CIHR [MOP-84535]
Aims: Vimentin, a type ill intermediate filament, is upregulated during epithelial mesenchymal transition and tumor progression. Vimentin is surface-expressed on cells involved in inflammation; the function remains unknown. We investigated the expression of surface vimentin on cancer cells and evaluated targeting nanoparticles to tumors exploiting vimentin. Materials & methods: Cowpea mosaic virus nanoparticles that interact with surface vimentin were used as probes. Tumor homing was tested using the chick chorioallantoic membrane model with human tumor xenografts. Results & discussion: Surface vimentin levels varied during cell cycle and among the cell lines tested. Surface vimentin expression correlated with cowpea mosaic virus uptake, underscoring the utility of cowpea mosaic virus to detect invasive cancer cells. Targeting to tumor xenografts was observed; homing was based on the enhanced permeability and retention effect. Our data provide novel insights into the role of surface vimentin in cancer and targeting nanoparticles in vivo.
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