期刊
NANOMEDICINE
卷 5, 期 9, 页码 1331-1340出版社
FUTURE MEDICINE LTD
DOI: 10.2217/NNM.10.88
关键词
cochlea; drug delivery; glucocorticoid; hair cell; hearing impairment; noise trauma
资金
- Japanese Ministry of Health, Labour and Welfare
Aims: This study aimed to investigate the efficacy of encapsulating steroids, which is a primary choice for the treatment of sensorineural hearing loss, in polyethylene glycol-coated polylactic acid nanoparticles for drug delivery to the cochlea. Materials & methods: We prepared polyethylene glycol-coated polylactic acid nanoparticles encapsulating rhodamine or betamethasone phosphate (BP), and administered them systemically to CBA/N mice previously exposed to intense noise. We assessed nanoparticle distribution using rhodamine fluorescence, BP concentrations in tissues, nuclear translocation of glucocorticoid receptors and the function and histology of the mouse cochleae. Results & conclusion: Polyethylene glycol-coated polylactic acid nanoparticles delivered BP to cochleae over a sustained period, resulting in significant reductions in histological and functional damage to cochleae and indicating the potential therapeutic benefits of these nanoparticles for enhancing the delivery of BP in acute sensorineural hearing loss.
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