期刊
NANOMEDICINE
卷 5, 期 4, 页码 575-587出版社
FUTURE MEDICINE LTD
DOI: 10.2217/NNM.10.28
关键词
autoradiography; biodistribution; brain targeting; micellar nanocarrier; sumatriptan
Aim: The investigation was aimed at designing a micellar nanocarrier of sumatriptan for nose-to-brain delivery and to identify the probable pathway of drug transport to the brain. Materials & methods: Micellar nanocarriers were formulated using various safe and acceptable excipients. Optimized formulation was characterized for particle size by multiangle dynamic light scattering, small-angle neutron scattering and cryo-transmission electron microscopy. Tc-99m was used as a radiolabeling agent to radiolabel sumatriptan for in vivo studies. Results: Various characterization studies demonstrated the nanometric, homogenous and spherical nature of the developed micellar nanocarrier. Biodistribution and autoradiography studies in rats showed a significantly higher brain uptake of sumatriptan micellar nanocarrier as compared with sumatriptan solution. Conclusion: Preliminary investigations in rats indicated the potential of the developed micellar nanocarrier for nose-to-brain delivery of sumatriptan. These investigations in lower animals provided an excellent lead to further evaluate the formulation in higher animals and finally in clinical settings.
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