期刊
NANOMEDICINE
卷 5, 期 3, 页码 451-468出版社
FUTURE MEDICINE LTD
DOI: 10.2217/NNM.10.18
关键词
apoptosis; drug delivery system; gold nanoparticles; magnetic resonance spectroscopic imaging; siRNA stimuli-responsive nanogel
资金
- Grant-in Aid fir Scientific Research (A) [1800033]
- Ministry of Education, Culture, Sports, Science and Technology of Japan (MEXT)
- Grants-in-Aid for Scientific Research [22710114] Funding Source: KAKEN
This article discusses stimuli-responsive poly(ethylene glycol) (PEG)-coated (PEGylated) nanogels and their biomedical applications. Preparation and characterization of stimuli-responsive PEGylated nanogels composed of a crosslinked poly(2-[N,N-diethylamino]ethyl methacrylate) (PEAMA) core and PEG tethered chains are initially described. Stimuli-responsive PEGylated nanogels show unique properties and functions in synchronizing with the reversible volume phase transition of the PEAMA core in response to the extracellular pH (7-6.5) of a tumor environment as well as endosomal/lysosomal pH (6.5-5.0) and temperature. We list several biomedical applications of stimuli-responsive PEGylated nanogels, including F-19 magnetic resonance spectroscopic imaging (MRS/I) probe to visualize acidosis (tumor tissue), intracellular drug and siRNA delivery, antennas for cancer photothermal therapy and apoptosis probe for monitoring response to cancer therapy. Thus, stimuli-responsive PEGylated nanogels can be utilized as smart nanomedicines for cancer diagnostics and therapy.
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