期刊
NANO TODAY
卷 6, 期 2, 页码 122-130出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.nantod.2011.02.004
关键词
Silicon nanowires; SERS; Hot spot; DNA detection
资金
- Research Grants Council of HKSAR [CityU5/CRF/08, N_CityU108/08]
- Ministry of Health [2009ZX10004-301]
- MOST [2006CB93000, 2007CB936000, 2010CB934500, 2006AA03Z302]
- NSFC [30900338, 20725516]
A nanostructured complex, silicon nanowires (SiNWs) coated with in situ grown AgNPs (SiNWs@AgNPs), is developed as a well-defined surface-enhanced Raman Scattering (SERS)-active platform for ultrasensitive DNA detection. Such SiNWs@AgNPs nanostructure possesses an extremely high SERS enhancement factor of similar to 10(10). We design a DNA sensor based on the nanostructure via immobilization of capture probe DNA at the surface of AgNPs, and a sandwich strategy for the detection of target DNA that brings a reporter probe labeled with a dye to the proximity of the surface, leading to high SERS signals. This silicon nanostructure-based biosensor platform can detect a remarkably low DNA concentration at similar to 1 fM, which is comparable to the lowest DNA concentration ever detected via SERS. We expect this highly sensitive and robust SiNWs-based SERS platform may serve as a practical and powerful tool for biomolecular sensing and biomedical analysis. (C) 2011 Elsevier Ltd. All rights reserved.
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