期刊
NANO TODAY
卷 6, 期 3, 页码 232-239出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.nantod.2011.05.001
关键词
Ultrasmall peptides; Self-assembly; Hydrogels; Tissue engineering
资金
- Institute of Bioengineering and Nanotechnology (Biomedical Research Council, Agency for Science, Technology and Research, Singapore)
A new class of systematically designed ultrasmall (tri- to heptamer) peptides presents the smallest natural, non-aromatic structures that self-assemble in water to hydrogels. The peptide motif consists of an aliphatic amino acid tail of decreasing hydrophobicity capped by a polar head. The fibrous scaffolds assemble from nanostructured aggregates to condensed three-dimensional (3D) meshes, entrapping up to 99.9% water and resembling collagen fibers in the extracellular matrix. The resulting hydrogels are biocompatible, heat resistant up to 90 degrees C and demonstrate tunable, high mechanical strength. Given their facile and cost-effective synthesis, these new materials would be attractive for applications ranging from injectable medical therapies to tissue-engineered scaffolds. (C) 2011 Elsevier Ltd. All rights reserved.
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