期刊
NANO RESEARCH
卷 7, 期 3, 页码 325-337出版社
TSINGHUA UNIV PRESS
DOI: 10.1007/s12274-013-0398-3
关键词
nanocomposites; gold nanorods; mesoporous silica; hematoporphyrin; photodynamic and photothermal therapy
类别
资金
- Russian Foundation for Basic Research [12-02-0379a, 11-02-0128a, 13-02-91176-NSFC_a, 12-02-92610-KO]
- Presidium of the Russian Academy of Sciences
- Russian Federation [1177.2012.2, 14.B37.21.0563, 14.B37.21.0728, 14.512.11.0022, 11.G.34.31.0030]
- FiDiPro, TEKES Program, Finland [40111/11]
- Russian Science Foundation [14-13-01167] Funding Source: Russian Science Foundation
Nanocomposites (NCs) consisting of a gold nanorod core and a mesoporous silica shell doped with hematoporphyrin (HP) have been fabricated in order to improve the efficiency of cancer treatment by combining photothermal and photodynamic therapies (PDT + PTT) in vivo. In addition to the long-wavelength plasmon resonance near 810-830 nm, the fabricated NCs exhibited a 400-nm absorbance peak corresponding to bound HP, generated singlet oxygen under 633-nm excitation near the 632.5-nm Q-band, and produced heat under a 808-nm near-infrared (NIR) laser irradiation. These modalities were used for a combined PDT + PTT treatment of large (about 3 cm(3)) solid tumors in vivo with a xenorafted tumor rat model. NCs were directly injected into tumors and irradiated simultaneously with 633-nm and 808-nm lasers to stimulate the combined photodynamic and photothermal activities of NCs. The efficiency of the combined therapy was evaluated by optical coherence tomography, histological analysis, and by measurements of the tumor volume growth during a 21-day period. The NC-mediated PDT led to weak changes in tissue histology and to a moderate 20% decrease in the tumor volume. In contrast, the combined PDT + PTT treatment resulted in the large-area tumor necrosis and led to dramatic decrease in the tumor volume.
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