期刊
NANO RESEARCH
卷 5, 期 3, 页码 199-212出版社
TSINGHUA UNIV PRESS
DOI: 10.1007/s12274-012-0200-y
关键词
Graphene oxide; magnetic nanocomposite; magnetic targeting; drug delivery; photothermal therapy; magnetic resonance imaging
类别
资金
- National Program on Key Basic Research Project (973 Program) [2012CB932600, 2011CB911002]
- National Natural Science Foundation of China [51132006, 51002100, 81171392, 81171394, K112218511]
- Natural Science Fund of Jiangsu Province [09KJB320016, SBK201122654]
- Natural Science Fund for Colleges and Universities in Jiangsu Province [09KJB320016]
Two-dimensional graphene and its composite nanomaterials offer interesting physical/chemical properties and have been extensively explored in a wide range of fields in recent years. In this work, we synthesize a multi-functional superparamagnetic graphene oxide-iron oxide hybrid nanocomposite (GO-IONP), which is then functionalized by a biocompatible polyethylene glycol (PEG) polymer to acquire high stability in physiological solutions. A chemotherapy drug, doxorubicin (DOX), was loaded onto GO-IONP-PEG, forming a GO-IONP-PEG-DOX complex, which enables magnetically targeted drug delivery. GO-IONP-PEG also exhibits strong optical absorbance from the visible to the near-infrared (NIR) region, and can be utilized for localized photothermal ablation of cancer cells guided by the magnetic field. Moreover, for the first time, in vivo magnetic resonance (MR) imaging of tumor-bearing mice is also demonstrated using GO-IONP-PEG as the T (2) contrast agent. Our work suggests the promise of using multifunctional GO-based nanocomposites for applications in cancer theranostics.
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