期刊
NANO RESEARCH
卷 4, 期 12, 页码 1248-1260出版社
TSINGHUA UNIV PRESS
DOI: 10.1007/s12274-011-0176-z
关键词
Nanocrystals; photothermal therapy; doxorubicin; hyperthermia; magnetic resonance imaging
类别
资金
- National Institute of Health [NIH-NCI 5R01CA135109-02]
Ultrasmall FeCo-graphitic carbon shell nanocrystals (FeCo/GC) are promising multifunctional materials capable of highly efficient drug delivery in vitro and magnetic resonance imaging in vivo. In this work, we demonstrate the use of FeCo/GC for highly effective cancer therapy through combined drug delivery, tumor-selective near-infrared photothermal therapy, and cancer imaging of a 4T1 syngeneic breast cancer model. The graphitic carbon shell of the similar to 4 nm FeCo/GC readily loads doxorubicin (DOX) via pi-pi stacking and absorbs near-infrared light giving photothermal heating. When used for cancer treatment, intravenously administrated FeCo/GC-DOX led to complete tumor regression in 45% of mice when combined with 20 min of near-infrared laser irradiation selectively heating the tumor to 43-45 A degrees C. In addition, the use of FeCo/GC-DOX results in reduced systemic toxicity compared with free DOX and appears to be safe in mice monitored for over 1 yr. FeCo/GC-DOX is shown to be a highly integrated nanoparticle system for synergistic cancer therapy leading to tumor regression of a highly aggressive tumor model.
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