期刊
NANO LETTERS
卷 14, 期 3, 页码 1551-1558出版社
AMER CHEMICAL SOC
DOI: 10.1021/nl404816m
关键词
Tobacco mosaic virus; magnetic resonance imaging; atherosclerosis; VCAM-1
类别
资金
- Mt. Sinai Foundation
- NIH training Grant [T32 HL105338]
- Natural Sciences and Engineering Research Council of Canada
- National Science Foundation Science and Technology Center for Layered Polymeric Systems (CLiPS) [DMR-0423914]
The underlying cause of major cardiovascular events, such as myocardial infarctions and strokes, is atherosclerosis. For accurate diagnosis of this inflammatory disease, molecular imaging is required. Toward this goal, we sought to develop a nanoparticle-based, high aspect ratio, molecularly targeted magnetic resonance (MR) imaging contrast agent. Specifically, we engineered the plant viral nanoparticle platform tobacco mosaic virus (TMV) to target vascular cell adhesion molecule (VCAM)-1, which is highly expressed on activated endothelial cells at atherosclerotic plaques. To achieve dual optical and MR imaging in an atherosclerotic ApoE(-/-) mouse model, TMV was modified to carry near-infrared dyes and chelated Gd ions. Our results indicate molecular targeting of atherosclerotic plaques. On the basis of the multivalency and multifunctionality, the targeted TMV-based MR probe increased the detection limit significantly; the injected dose of Gd ions could be further reduced 400x compared to the suggested clinical use, demonstrating the utility of targeted nanoparticle cargo delivery.
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