期刊
NANO LETTERS
卷 14, 期 10, 页码 5721-5726出版社
AMER CHEMICAL SOC
DOI: 10.1021/nl502498w
关键词
Multiplexing; cell-labeling; MRI; xenon; hyperpolarization; CEST
We demonstrate a concept for multichannel MRI cell-labeling using encapsulated laser-polarized xenon. Conceptually different Xe trapping properties of two nanocarriers, namely macrocyclic cages as individual hosts or compartmentalization into nanodroplets, ensure a large chemical shift separation for Xe bound in either of the carriers even after cellular internalization. Two differently labeled mammalian cell populations were imaged by frequency selective saturation transfer resulting in a switchable two-color xenon-MRI contrast at micro- to nanomolar Xe carrier concentrations.
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