4.8 Article

Single-Walled Carbon Nanotubes Alleviate Autophagic/Lysosomal Defects in Primary Glia from a Mouse Model of Alzheimer's Disease

期刊

NANO LETTERS
卷 14, 期 9, 页码 5110-5117

出版社

AMER CHEMICAL SOC
DOI: 10.1021/nl501839q

关键词

Single-walled carbon nanotubes; primary glia; autophagy; Alzheimers disease

资金

  1. Chinese Natural Science Foundation [81171455]
  2. National Natural Science Foundation of China [31225009]
  3. National Key Basic Research Program of China [2009CB930200]
  4. Chinese Academy of Sciences (CAS) [07165111ZX]
  5. CAS Knowledge Innovation Program
  6. State High-Tech Development Plan [2012AA020804, SS2014AA020708]
  7. Strategic Priority Research Program of the Chinese Academy of Sciences [XDA09030301]
  8. U.S. National Institute on Aging [P01AG017617]
  9. Takeda Pharmaceuticals, Ltd

向作者/读者索取更多资源

Defective autophagy in Alzheimer's disease (AD) promotes disease progression in diverse ways. Here, we demonstrate impaired autophagy flux in primary glial cells derived from CRND8 mice that overexpress mutant amyloid precursor protein (APP). Functionalized single-walled carbon nanotubes (SWNT) restored normal autophagy by reversing abnormal activation of mTOR signaling and deficits in lysosomal proteolysis, thereby facilitating elimination of autophagic substrates. These findings suggest SWNT as a novel neuroprotective approach to AD therapy.

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