期刊
NANO LETTERS
卷 15, 期 1, 页码 96-102出版社
AMER CHEMICAL SOC
DOI: 10.1021/nl504123r
关键词
NIR II; SWIR; second near-infrared; rare-earth; imaging; X-ray luminescence
类别
资金
- NIBIB [1R01 EB016777]
- NCI [1R01 CA133474]
- U.S. Department of Defense [W81XWH-11-1-0087]
Shortwave infrared (SWIR or NIR-II) light provides significant advantages for imaging biological structures due to reduced autofluorescence and photon scattering. Here, we report on the development of rare-earth nanoprobes that exhibit SWIR luminescence following X-ray irradiation. We demonstrate the ability of X-ray-induced SWIR luminescence (X-IR) to monitor biodistribution and map lymphatic drainage. Our results indicate X-IR imaging is a promising new modality for preclinical applications and has potential for dual-modality molecular disease imaging.
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