期刊
NANO LETTERS
卷 14, 期 2, 页码 1049-1055出版社
AMER CHEMICAL SOC
DOI: 10.1021/nl404727m
关键词
Cell membrane; nanotubes; cell interaction; microtubule; filopodia; molecular dynamics
类别
资金
- National Science Foundation under INSPIRE: Computational Design for the Safe Development of High-Aspect-Ratio Nanomaterials [GBET-1344097, CMMI-1028530]
- National Natural Science Foundation of China [11272327, 11023001]
- Div Of Civil, Mechanical, & Manufact Inn
- Directorate For Engineering [1028530] Funding Source: National Science Foundation
Understanding cell interaction with one-dimensional nanomaterials, including nanotubes, nanowires, nanofibers, filamentous bacteria, and certain nanoparticle chains, has fundamental importance to many applications such as biomedical diagnostics, therapeutics, and nanotoxicity. Here we show that cell uptake of one-dimensional nanomaterials via receptor-mediated endocytosis is dominated by a single dimensionless parameter that scales with the membrane tension and radius of the nanomaterial and inversely with the membrane bending stiffness. It is shown that as cell membrane internalizes one-dimensional nanomaterials the uptake follows a near-perpendicular entry mode at small membrane tension but it switches to a near-parallel interaction mode at large membrane tension.
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