期刊
NANO LETTERS
卷 13, 期 6, 页码 2576-2583出版社
AMER CHEMICAL SOC
DOI: 10.1021/nl400681f
关键词
Mesoporous silica nanoparticles; nanoparticle drug delivery; targeting cancer cells; folic acid; epidermal growth factor; photosensitizer
类别
资金
- Nanosystems Initiative Munich (NIM)
- Center for NanoScience Munich (CeNS), DFG [SFB 749]
- Center for Integrated Protein Science Munich (CIPSM)
Mesoporous nanoparticles for drug delivery would benefit significantly from further improvements in targeting efficiency and endosomal release. We present a system based on colloidal mesoporous silica nanoparticles with targeting-ligands and a red-light photosensitizer. This nanoparticle system provides spatial and temporal control of the release of drugs into the cytosol of cancer cells. Furthermore, the system presents a general platform since it can be loaded with different cargos and adapted for targeting of multiple cell types.
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