期刊
NANO LETTERS
卷 13, 期 7, 页码 3185-3192出版社
AMER CHEMICAL SOC
DOI: 10.1021/nl401237s
关键词
Nanomembranes; nanomechanical properties; extracellular matrix; carbon nanotubes; skeletal muscle cells
类别
资金
- World Premier International Research Center Initiative (WPI)
- JSPS KAKENHI from MEXT, Japan [25870050]
- Grants-in-Aid for Scientific Research [23681027, 25870050] Funding Source: KAKEN
Controlling the cellular microenvironment can be used to direct the cellular organization, thereby improving the function of synthetic tissues in biosensing, biorobotics and regenerative medicine. In this study, we were inspired by the microstructure and biological properties of the extracellular matrix, to develop freestanding ultrathin polymeric films (referred as nanomembranes) that were flexible, cell adhesive, and had a morphologically tailorable surface. The resulting nanomembranes were exploited as flexible substrates, on which cell-adhesive micropatterns were generated to align C2C12 skeletal myoblasts and embedded fibril carbon nanotubes (CNTs) enhanced the cellular elongation and differentiation. Functional nanomembranes with tunable morphology and mechanical properties hold great promise in studying cell-substrate interactions and in fabricating biomimetic constructs towards flexible biodevices.
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