期刊
NANO LETTERS
卷 14, 期 1, 页码 83-88出版社
AMER CHEMICAL SOC
DOI: 10.1021/nl4032549
关键词
Nanoparticles; nanobio interactions; cell migration; microtubules; cell traction force
类别
资金
- Ministry of Education [R-279-000-350-112, R279-000-376-112]
- Faculty of Engineering Strategic Research Fund [R-397-000-136-112]
- Lee Kuan Yew Postdoctoral Fellowship
Nanoparticles can have profound effects on cell biology. Here, we show that after TiO2, SiO2, and hydroxyapatite nanoparticles treatment, TR146 epithelial cell sheet displayed slower migration. Cells after exposure to the nanoparticles showed increased cell contractility with significantly impaired wound healing capability however without any apparent cytotoxicity. We showed the mechanism is through nanoparticle-mediated massive disruption of the intracellular microtubule assembly, thereby triggering a positive feedback that promoted stronger substrate adhesions thus leading to limited cell motility.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据