期刊
NANO LETTERS
卷 13, 期 2, 页码 581-585出版社
AMER CHEMICAL SOC
DOI: 10.1021/nl304111v
关键词
Gold nanocages; cancer imaging; Cerenkov luminescence imaging; radioactive
类别
资金
- NCI [R01 CA13852701]
- NIH [DP1 OD000798]
- Georgia Institute of Technology
Cerenkov luminescence imaging based on light emission from the decay of radionuclides has recently drawn great interest in molecular imaging. In this paper, we report for the first time the Cerenkov luminescence phenomenon of Au-198 isotope, as well as a facile route to the preparation of radioluminescent Au nanocages without additional radiolabeling or dye conjugation. The specific radioactivity of the Au nanocages could be easily and precisely controlled by varying the concentration of (HAuCl4)-Au-198 precursor used for the galvanic replacement reaction. The direct incorporation of Au-198 atoms into the structure of Au nanocages enabled the ability of accurate analysis and real-time imaging in vivo. Furthermore, under biological conditions the radioactive Au nanocages were shown to emit light with wavelengths in the visible and near-infrared regions, enabling luminescence imaging of the whole mice in vivo, as well as the organs ex vivo. When combined with their favorable scattering and absorption properties in the near-infrared region, the radioactive Au nanocages can serve as a new platform for multimodality imaging and will have a significant impact on both small animal and clinical imaging.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据