期刊
NANO LETTERS
卷 13, 期 12, 页码 6275-6280出版社
AMER CHEMICAL SOC
DOI: 10.1021/nl403884w
关键词
DNA; rotaxane; machine; nanoparticle; fluorescence; switch
类别
资金
- Israel Science Foundation
- NanoSensoMach ERC Advanced Grant under the EC [267574]
- European Research Council (ERC) [267574] Funding Source: European Research Council (ERC)
The preparation of a DNA rotaxane consisting of a circular nucleic acid interlocked, through hybridization, on a nucleic acid axle and stoppered by two 10-nm-sized Au nanoparticles (NPs) is described. By the tethering of 5-nm- or 15-nm-sized Au NPs on the ring, the supramolecular structure of the rotaxane is confirmed. Using nucleic acids as fuels and anti-fuels, the cyclic and reversible transition of the rotaxane ring across two states is demonstrated. By the fiinctionalization of the ring with fluorophore-modified nucleic acids in different orientations, the transitions of the rings between the sites are followed by fluorescence quenching or surface-enhanced fluorescence. The experimental results are supported by theoretical modeling.
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