期刊
NANO LETTERS
卷 12, 期 4, 页码 2165-2170出版社
AMER CHEMICAL SOC
DOI: 10.1021/nl300630c
关键词
Polypeptides; block copolymers; stimulus-responsive; pH responsive; tumor drug delivery
类别
资金
- NIH [R01EB007205]
- Triangle MRSEC through NSF DMR
- NSF [NSF-DGE-02-21632]
- Center for Interventional Oncology of NIH
- Division Of Materials Research
- Direct For Mathematical & Physical Scien [1121107] Funding Source: National Science Foundation
To address the limited tumor penetration of nanoparticle drug delivery vehicles, we report the first pH-responsive polypeptide micelle that dissociates at the low extracellular pH of solid tumors. This histidine-rich elastin-like polypeptide block copolymer self-assembles at 37 degrees C into spherical micelles that are stabilized by Zn2+ and are disrupted as the pH drops from 7.4 to 6.4. These pH-sensitive micelles demonstrate better in vivo penetration and distribution in tumors than a pH-insensitive control.
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