期刊
NANO LETTERS
卷 12, 期 4, 页码 1831-1838出版社
AMER CHEMICAL SOC
DOI: 10.1021/nl204064s
关键词
Carbon nanotubes; cardiac myocytes; tissue engineering; cardiomyocyte electrophysiology
类别
资金
- Foreman-Casali Foundation, Trieste (Italy)
- EU [NEURONANO-NMP4-CT-2006-031847, CARBONANOBRIDGE- ERC-2008-227135]
- Italian Ministry of Education MIUR [Cofin Prot. 20085M27SS]
Nanoscale manipulations of the extracellular microenvironment are increasingly attracting attention in tissue engineering. Here, combining microscopy, biological, and single-cell electrophysiological methodologies, we demonstrate that neonatal rat ventricular myocytes cultured on substrates of multiwall carbon nanotubes interact with carbon nanotubes by forming tight contacts and show increased viability and proliferation. Furthermore, we observed changes in the electrophysiological properties of cardiomyocytes, suggesting that carbon nanotubes are able to promote cardiomyocyte maturation.
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