期刊
NANO LETTERS
卷 12, 期 6, 页码 3127-3131出版社
AMER CHEMICAL SOC
DOI: 10.1021/nl3010308
关键词
Nanoparticle; nanomedicine; iron oxide; magnetic resonance imaging contrast agent; colloidal stability
类别
资金
- National Research Foundation (NRF) of Korea through Strategic Research [2010-0029138]
- Global Research Laboratory [2011-0021628]
- World Class University [R31-10013]
- Ministry for Health, Welfare, and Family Affairs [A112028]
The theoretically predicted maximum r(2) relaxivity of iron oxide nanoparticles was achieved by optimizing the overall size of ferrimagnetic iron oxide nanocubes. Uniform-sized iron oxide nanocubes with an edge length of 22 nm, encapsulated with PEG-phospholipids (WFION), exhibited high colloidal stability in aqueous media. In addition, WFIONs are biocompatible and did not affect cell viability at concentrations up to 0.75 mg Fe/ml. Owing to the enhanced colloidal stability and the high r(2) relaxivity (761 mM(-1) s(-1)), it was possible to successfully perform in vivo MR imaging of tumors by intravenous injection of 22-nm-sized WFIONs, using a clinical 3-T MR scanner.
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