期刊
NANO LETTERS
卷 12, 期 6, 页码 2901-2905出版社
AMER CHEMICAL SOC
DOI: 10.1021/nl3004896
关键词
Phagocytosis; macrophages; aspect ratio; target shape; filamentation; E. coli
类别
资金
- Competence Center for Materials Science and Technology CCMX MaLife [0-21154-07]
- Ciba Speciality Chemicals, Basel, Switzerland
- BASF, Ludwig-shafen, Germany [2-70627-05]
- ETH Zurich, Switzerland
- ERC [EU-23157]
While bioengineers ask how the shape of diagnostic and therapeutic particles impacts their pharmacological efficiency, biodistribution, and toxicity, microbiologists suggested that morphological adaptations enable pathogens to perhaps evade the immune response. Here, a shape-dependent process is described that limits phagocytosis of filamentous Escherichia coli bacteria by macrophages: successful uptake requires access to one of the terminal bacterial filament poles. By exploiting micropatterned surfaces, we further demonstrate that microenvironmental heterogeneities can slow or inhibit phagocytosis. A comparison to existing literature reveals a common shape-controlled uptake mechanism for both high-aspect ratio filamentous bacteria and engineered particles.
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