期刊
NANO LETTERS
卷 12, 期 12, 页码 6453-6458出版社
AMER CHEMICAL SOC
DOI: 10.1021/nl3039162
关键词
DNA bundles direct imaging; transmission electron microscopy; superhydrophobic surface; nanofabricated micropillars; molecular dynamics simulations
类别
资金
- European Project [SMD FP7-NMP 2800-SMALL-2, CP-FP 229375-2]
- Single Molecule Activation and Computing (FOCUS) project under seventh Framework Programme [270483]
Direct imaging becomes important when the knowledge at few/single molecule level is requested and where the diffraction does not allow to get structural and functional information. Here we report on the direct imaging of double stranded (ds) lambda-DNA in the A conformation, obtained by combining a novel sample preparation method based on super hydrophobic DNA molecules self-aggregation process with transmission electron microscopy (TEM). The experimental breakthrough is the production of robust and highly ordered paired DNA nanofibers that allowed its direct TEM imaging and the double helix structure revealing.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据