期刊
NANO LETTERS
卷 12, 期 5, 页码 2509-2514出版社
AMER CHEMICAL SOC
DOI: 10.1021/nl300679e
关键词
Grafted-nanoparticles; DNA; spherical nucleic acid; guided assembly; crystallization
类别
资金
- Defense Research and Engineering Multidisciplinary University Research Initiative of the Air Force Office of Scientific Research [FA9550-11-1-0275]
- DoD NSSEFF [FA9550-10-1-0167]
- Northwestern Nonequilibrium Energy Research Center from the DOE [DE-SC0000989]
- Northwestern University
We use molecular dynamics simulations to study the crystallization of spherical nucleic-acid (SNA) gold nanoparticle conjugates, guided by sequence-specific DNA hybridization events. Binary mixtures of SNA gold nanoparticle conjugates (inorganic core diameter in the 8-15 nm range) are shown to assemble into BCC, CsCl, AlB2, and Cr3Si crystalline structures, depending upon particle stoichiometry, number of immobilized strands of DNA per particle, DNA sequence length, and hydrodynamic size ratio of the conjugates involved in crystallization. These data have been used to construct phase diagrams that are in excellent agreement with experimental data from wet-laboratory studies.
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