期刊
NANO LETTERS
卷 12, 期 12, 页码 6441-6447出版社
AMER CHEMICAL SOC
DOI: 10.1021/nl303820a
关键词
Nanochannel; membrane potential; electrofluidic gating; ion transport; salinity gradient power
类别
资金
- Howard Hughes Medical Institute
Biological ion channels are molecular devices that allow a rapid flow of ions across the cell membrane. Normal physiological functions, such as generating action potentials for cell-to-cell communication, are highly dependent on ion channels that can open and close in response to external stimuli for regulating ion permeation. Mimicking these biological functions using synthetic structures is a rapidly progressing yet challenging area. Here we report the electric field modulation of the membrane potential phenomena in mechanically and chemically robust solid-state ion channels, an abiotic analogue to the voltage-gated ion channels in living systems. To understand the complex physicochemical processes in the electric field regulated membrane potential behavior, both quasi-static and transient characteristics of converting transmembrane ion gradients into electric potential are investigated. It is found that the transmembrane potential can be adequately tuned by an external electrical stimulation, thanks to the unique properties of the voltage-regulated selective ion transport through a nanoscale channel.
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