期刊
SENSORS AND ACTUATORS B-CHEMICAL
卷 220, 期 -, 页码 500-507出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.snb.2015.05.096
关键词
Ion-sensitive field-effect transistor; Calcium sensing; Site-binding model; Competing surface reactions; Gold-coated nanoribbons
资金
- Swiss Nanoscience Institute (SNI)
- Swiss Nano-Tera program [20NAN1_123611]
- European Commission [263091, 105244]
- Swiss National Science Foundation as part of the NCCR Molecular Systems Engineering
Ion-sensitive field-effect transistors based on silicon nanowires are promising candidates for the detection of chemical and biochemical species. These devices have been established as pH sensors thanks to the large number of surface hydroxyl groups at the gate dielectrics which makes them intrinsically sensitive to protons. To specifically detect species other than protons, the sensor surface needs to be modified. However, the remaining hydroxyl groups after functionalization may still limit the sensor response to the targeted species. Here, we describe the influence of competing reactions on the measured response using a general site-binding model. We investigate the key features of the model with a real sensing example based on gold-coated nanoribbons functionalized with a self-assembled monolayer of calcium-sensitive molecules. We identify the residual pH response as the key parameter limiting the sensor response. The competing effect of pH or any other relevant reaction at the sensor surface has therefore to be included to quantitatively understand the sensor response and prevent misleading interpretations. (C) 2015 Elsevier B.V. All rights reserved.
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