期刊
NANO LETTERS
卷 12, 期 6, 页码 3050-3061出版社
AMER CHEMICAL SOC
DOI: 10.1021/nl300895y
关键词
Multiwalled carbon nanotubes (MWCNTs); pluronic copolymer; biocompatible; dispersion; lung fibrosis
类别
资金
- U.S. Public Health Service [R01 ES016746, U19 ES019528]
- National Science Foundation [DBI-0830117]
- Environmental Protection Agency [DBI-0830117]
- U.S. National Science Foundation [DMR-1006391]
- Division Of Materials Research
- Direct For Mathematical & Physical Scien [1006391] Funding Source: National Science Foundation
We compared the use of bovine serum albumin (BSA) and pluronic F108 (PF108) as dispersants for multiwalled carbon nanotubes (MWCNTs) in terms of tube stability as well as profibrogenic effects in vitro and in vivo. While BSA-dispersed tubes were a potent inducer of pulmonary fibrosis, PF108 coating protected the tubes from damaging the lysosomal membrane and initiating a sequence of cooperative cellular events that play a role in the pathogenesis of pulmonary fibrosis. Our results suggest that PF108 coating could serve as a safer design approach for MWCNTs.
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