期刊
NANO LETTERS
卷 12, 期 4, 页码 1826-1830出版社
AMER CHEMICAL SOC
DOI: 10.1021/nl204058u
关键词
DNA-SWCNT; nanotubes; HUVEC; endothelial; internalization; pinocytosis
类别
资金
- National Institutes of Health (NIH) [HL70567, CA150190]
- National Science Foundation (NSF) [CMMI-1014960]
- Lehigh University
- Directorate For Engineering
- Div Of Civil, Mechanical, & Manufact Inn [1014960] Funding Source: National Science Foundation
Several applications of single-walled carbon nanotubes (SWCNT) as nanovectors in biological systems have been reported, and several molecular pathways of cellular entry have been proposed. We employed transmission electron microscopy, confocal fluorescent microscopy, and UV-vis spectroscopic analysis to confirm the internalization of DNA-SWCNT in human umbilical vein endothelial cells. Additionally, by using pharmacological inhibitors as well as genetic approaches, we have found that SWCNT is endocytosed through Rac1- GTPase mediated macropinocytosis in normal endothelial cells.
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